Drug interactions
Enalapril-hydrochlorothiazide + Gold sodium thiomalate
Severity: Moderate
Enalapril-hydrochlorothiazide and Gold sodium thiomalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injectable gold has been associated with nitritoid reactions, including flushing, nausea, vomiting and hypotension, and these appear more frequent in patients taking ACE inhibitors. Reactions can be distressing and may cause significant hypotension.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Not fully established; possibly ACE inhibitor-related impaired bradykinin breakdown and vasodilation with gold-induced vasomotor effects.
What to do
Consider an alternative to the ACE inhibitor in patients starting injectable gold. If used together, observe the patient after injection and monitor blood pressure, stopping gold if reactions recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Gold sodium thiomalate?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injectable gold has been associated with nitritoid reactions, including flushing, nausea, vomiting and hypotension, and these appear more frequent in patients taking ACE inhibitors. Reactions can be distressing and may cause significant hypotension.
How serious is the interaction between Enalapril-hydrochlorothiazide and Gold sodium thiomalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative to the ACE inhibitor in patients starting injectable gold. If used together, observe the patient after injection and monitor blood pressure, stopping gold if reactions recur.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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