Drug interactions
Enalapril-hydrochlorothiazide + Heparin
Severity: Moderate
Enalapril-hydrochlorothiazide and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin suppresses adrenal aldosterone synthesis, which can cause hyperkalemia. Combined with an ACE inhibitor, which also lowers aldosterone, the risk of raised potassium increases, particularly in patients with renal impairment or diabetes.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Heparin inhibits aldosterone secretion, adding to ACE inhibitor-mediated reduction of aldosterone and potassium excretion.
What to do
Monitor serum potassium and renal function, especially with prolonged heparin therapy or in high-risk patients. Treat hyperkalemia or review therapy if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enalapril-hydrochlorothiazide and Heparin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Heparin?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin suppresses adrenal aldosterone synthesis, which can cause hyperkalemia. Combined with an ACE inhibitor, which also lowers aldosterone, the risk of raised potassium increases, particularly in patients with renal impairment or diabetes.
How serious is the interaction between Enalapril-hydrochlorothiazide and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially with prolonged heparin therapy or in high-risk patients. Treat hyperkalemia or review therapy if potassium rises.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
