Drug interactions
Enalapril-hydrochlorothiazide + Hydrocortisone
Severity: Moderate
Enalapril-hydrochlorothiazide and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone has mineralocorticoid activity and can promote potassium loss, which adds to that caused by hydrochlorothiazide. Hypokalemia may result, particularly with higher or prolonged corticosteroid doses. Corticosteroids can also raise blood pressure and blunt the antihypertensive effect.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from corticosteroid mineralocorticoid effect and thiazide diuresis.
What to do
Monitor serum potassium and blood pressure during combined therapy and supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Hydrocortisone?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone has mineralocorticoid activity and can promote potassium loss, which adds to that caused by hydrochlorothiazide. Hypokalemia may result, particularly with higher or prolonged corticosteroid doses. Corticosteroids can also raise blood pressure and blunt the antihypertensive effect.
How serious is the interaction between Enalapril-hydrochlorothiazide and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during combined therapy and supplement potassium if needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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