Drug interactions
Enalapril-hydrochlorothiazide + Indacaterol inhaled
Severity: Moderate
Enalapril-hydrochlorothiazide and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a long-acting beta2-agonist, can lower serum potassium, and thiazides cause renal potassium loss. Together hypokalemia may be more pronounced and could increase arrhythmia risk, especially with hypoxia.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta2-mediated intracellular potassium shift additive to thiazide-induced kaliuresis.
What to do
Monitor serum potassium periodically, particularly in patients with severe COPD or cardiac disease. Correct hypokalemia and magnesium deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a long-acting beta2-agonist, can lower serum potassium, and thiazides cause renal potassium loss. Together hypokalemia may be more pronounced and could increase arrhythmia risk, especially with hypoxia.
How serious is the interaction between Enalapril-hydrochlorothiazide and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, particularly in patients with severe COPD or cardiac disease. Correct hypokalemia and magnesium deficits.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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