Drug interactions
Enalapril-hydrochlorothiazide + Indapamide
Severity: Moderate
Enalapril-hydrochlorothiazide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and indapamide are both thiazide-type diuretics. Combining them gives additive diuresis, with greater risk of hypokalemia, hyponatremia, hypomagnesemia and volume depletion, though enalapril partly offsets potassium loss.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Duplicate inhibition of the distal tubule sodium-chloride cotransporter leads to additive electrolyte and fluid loss.
What to do
Avoid duplicate thiazide-type therapy where possible. If used together, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Indapamide
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Indapamide?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide and indapamide are both thiazide-type diuretics. Combining them gives additive diuresis, with greater risk of hypokalemia, hyponatremia, hypomagnesemia and volume depletion, though enalapril partly offsets potassium loss.
How serious is the interaction between Enalapril-hydrochlorothiazide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide-type therapy where possible. If used together, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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