Drug interactions
Enalapril-hydrochlorothiazide + Insulin lispro
Severity: Moderate
Enalapril-hydrochlorothiazide and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and may increase the risk of hypoglycemia in insulin-treated patients. The thiazide component may raise glucose and partly oppose this effect.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Insulin lispro belongs to Endocrine.
Why it happens
ACE inhibition may improve insulin sensitivity, while thiazides may reduce glucose tolerance.
What to do
Monitor blood glucose, particularly in the first weeks of combined use. Adjust the insulin dose if hypoglycemia or hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Insulin lispro
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Insulin lispro?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and may increase the risk of hypoglycemia in insulin-treated patients. The thiazide component may raise glucose and partly oppose this effect.
How serious is the interaction between Enalapril-hydrochlorothiazide and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, particularly in the first weeks of combined use. Adjust the insulin dose if hypoglycemia or hyperglycemia develops.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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