Drug interactions
Enalapril-hydrochlorothiazide + Levalbuterol
Severity: Moderate
Enalapril-hydrochlorothiazide and Levalbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levalbuterol, a beta2-agonist, can lower serum potassium, particularly at high doses. With a thiazide the hypokalemia may be additive and raise arrhythmia risk.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta2-mediated cellular potassium uptake plus thiazide-induced renal potassium loss.
What to do
Monitor serum potassium when levalbuterol is used frequently or in high doses, and replace potassium as needed, particularly in cardiac patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Levalbuterol?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levalbuterol, a beta2-agonist, can lower serum potassium, particularly at high doses. With a thiazide the hypokalemia may be additive and raise arrhythmia risk.
How serious is the interaction between Enalapril-hydrochlorothiazide and Levalbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when levalbuterol is used frequently or in high doses, and replace potassium as needed, particularly in cardiac patients.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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