Drug interactions
Enalapril-hydrochlorothiazide + Magnesium chloride
Severity: Minor
Enalapril-hydrochlorothiazide and Magnesium chloride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide increases urinary magnesium loss, which can lower serum magnesium over time and offset magnesium supplementation.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Magnesium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-induced increase in renal magnesium excretion.
What to do
Monitor serum magnesium in patients on long-term therapy and adjust the magnesium dose if levels remain low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Magnesium chloride?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Magnesium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide increases urinary magnesium loss, which can lower serum magnesium over time and offset magnesium supplementation.
How serious is the interaction between Enalapril-hydrochlorothiazide and Magnesium chloride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium in patients on long-term therapy and adjust the magnesium dose if levels remain low.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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