Drug interactions
Enalapril-hydrochlorothiazide + Magnesium sulfate
Severity: Minor
Enalapril-hydrochlorothiazide and Magnesium sulfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics promote renal magnesium wasting and can contribute to hypomagnesemia. Magnesium sulfate given as replacement may be needed more often in patients on long-term thiazide therapy.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Hydrochlorothiazide increases renal magnesium excretion, opposing magnesium repletion.
What to do
Monitor serum magnesium and renal function when giving magnesium sulfate and adjust the replacement dose to the measured level.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enalapril-hydrochlorothiazide and Magnesium sulfate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Magnesium sulfate?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics promote renal magnesium wasting and can contribute to hypomagnesemia. Magnesium sulfate given as replacement may be needed more often in patients on long-term thiazide therapy.
How serious is the interaction between Enalapril-hydrochlorothiazide and Magnesium sulfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and renal function when giving magnesium sulfate and adjust the replacement dose to the measured level.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
