Drug interactions
Enalapril-hydrochlorothiazide + Meclofenamate
Severity: Moderate
Enalapril-hydrochlorothiazide and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, like other NSAIDs, can reduce the blood pressure lowering effect of ACE inhibitors and thiazides. Together with a diuretic and ACE inhibitor it increases the risk of acute kidney injury, particularly in older or volume-depleted patients.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion.
What to do
Use the lowest effective NSAID dose for the shortest time or choose acetaminophen; monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Meclofenamate?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, like other NSAIDs, can reduce the blood pressure lowering effect of ACE inhibitors and thiazides. Together with a diuretic and ACE inhibitor it increases the risk of acute kidney injury, particularly in older or volume-depleted patients.
How serious is the interaction between Enalapril-hydrochlorothiazide and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time or choose acetaminophen; monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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