Drug interactions
Enalapril-hydrochlorothiazide + Mipomersen
Severity: Moderate
Enalapril-hydrochlorothiazide and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises transaminases and causes hepatic steatosis. Enalapril can rarely cause liver injury, so combined use may complicate liver safety assessment.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential for hepatotoxicity; the mechanism is not well established.
What to do
Monitor liver enzymes and bilirubin per mipomersen requirements. Interrupt therapy if significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Mipomersen?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises transaminases and causes hepatic steatosis. Enalapril can rarely cause liver injury, so combined use may complicate liver safety assessment.
How serious is the interaction between Enalapril-hydrochlorothiazide and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin per mipomersen requirements. Interrupt therapy if significant elevations occur.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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