Drug interactions
Enalapril-hydrochlorothiazide + Noni juice
Severity: Moderate
Enalapril-hydrochlorothiazide and Noni juice: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Noni juice has a high potassium content and can raise serum potassium. Enalapril also retains potassium, so hyperkalemia is possible, especially in patients with kidney impairment, although the thiazide partially offsets this.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dietary potassium load combines with ACE inhibitor-induced reduction in aldosterone-mediated potassium excretion, partly countered by thiazide kaliuresis.
What to do
Advise avoiding regular noni juice intake, particularly with renal impairment, and check serum potassium if it is consumed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Noni juice?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Noni juice has a high potassium content and can raise serum potassium. Enalapril also retains potassium, so hyperkalemia is possible, especially in patients with kidney impairment, although the thiazide partially offsets this.
How serious is the interaction between Enalapril-hydrochlorothiazide and Noni juice?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding regular noni juice intake, particularly with renal impairment, and check serum potassium if it is consumed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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