Drug interactions
Enalapril-hydrochlorothiazide + Olanzapine / samidorphan
Severity: Moderate
Enalapril-hydrochlorothiazide and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may enhance the effect of antihypertensives. Patients taking enalapril-hydrochlorothiazide may therefore experience dizziness or falls, particularly early in treatment.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from alpha-adrenergic blockade by olanzapine and the antihypertensive agents.
What to do
Monitor blood pressure and orthostatic symptoms during initiation and dose changes, and reduce the antihypertensive dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension and may enhance the effect of antihypertensives. Patients taking enalapril-hydrochlorothiazide may therefore experience dizziness or falls, particularly early in treatment.
How serious is the interaction between Enalapril-hydrochlorothiazide and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during initiation and dose changes, and reduce the antihypertensive dose if needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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