Drug interactions
Enalapril-hydrochlorothiazide + Penicillin g aqueous
Severity: Minor
Enalapril-hydrochlorothiazide and Penicillin g aqueous: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and penicillins may compete for renal tubular secretion, which can modestly raise penicillin concentrations. High-dose aqueous penicillin G also delivers a sodium or potassium load.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion.
What to do
Usually no adjustment is needed. Monitor renal function and electrolytes during high-dose penicillin G therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Penicillin g aqueous?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and penicillins may compete for renal tubular secretion, which can modestly raise penicillin concentrations. High-dose aqueous penicillin G also delivers a sodium or potassium load.
How serious is the interaction between Enalapril-hydrochlorothiazide and Penicillin g aqueous?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no adjustment is needed. Monitor renal function and electrolytes during high-dose penicillin G therapy.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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