Drug interactions
Enalapril-hydrochlorothiazide + Phenoxybenzamine
Severity: Moderate
Enalapril-hydrochlorothiazide and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine is an irreversible alpha-blocker that causes marked vasodilation. With an ACE inhibitor and thiazide, pronounced orthostatic hypotension may occur, especially early in therapy.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilatory hypotensive effects.
What to do
Titrate phenoxybenzamine slowly and monitor supine and standing blood pressure. Reduce other antihypertensives if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine is an irreversible alpha-blocker that causes marked vasodilation. With an ACE inhibitor and thiazide, pronounced orthostatic hypotension may occur, especially early in therapy.
How serious is the interaction between Enalapril-hydrochlorothiazide and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate phenoxybenzamine slowly and monitor supine and standing blood pressure. Reduce other antihypertensives if hypotension occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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