Drug interactions
Enalapril-hydrochlorothiazide + Potassium acid
Severity: Major
Enalapril-hydrochlorothiazide and Potassium acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enalapril reduces aldosterone and thus renal potassium excretion, so potassium acid phosphate supplements can cause hyperkalemia. The thiazide partly offsets this, but the risk remains, especially with renal impairment or diabetes.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Potassium acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
ACE inhibitor-induced reduction in aldosterone and renal potassium excretion adds to an exogenous potassium load.
What to do
Check serum potassium and renal function before and shortly after starting supplementation, then periodically. Reduce or stop the supplement if potassium rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Potassium acid?
MediHelp rates the interaction as major. Enalapril-hydrochlorothiazide and Potassium acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enalapril reduces aldosterone and thus renal potassium excretion, so potassium acid phosphate supplements can cause hyperkalemia. The thiazide partly offsets this, but the risk remains, especially with renal impairment or diabetes.
How serious is the interaction between Enalapril-hydrochlorothiazide and Potassium acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function before and shortly after starting supplementation, then periodically. Reduce or stop the supplement if potassium rises.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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