Drug interactions
Enalapril-hydrochlorothiazide + Promazine
Severity: Moderate
Enalapril-hydrochlorothiazide and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine, a phenothiazine with alpha-blocking and sedative properties, can add to the blood pressure lowering of enalapril and hydrochlorothiazide. Orthostatic hypotension and dizziness may occur, particularly in older patients.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect through alpha-adrenergic blockade combined with ACE inhibition and diuresis.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing promazine, and reduce antihypertensive doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Promazine?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine, a phenothiazine with alpha-blocking and sedative properties, can add to the blood pressure lowering of enalapril and hydrochlorothiazide. Orthostatic hypotension and dizziness may occur, particularly in older patients.
How serious is the interaction between Enalapril-hydrochlorothiazide and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing promazine, and reduce antihypertensive doses if hypotension develops.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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