Drug interactions
Enalapril-hydrochlorothiazide + Propranolol
Severity: Minor
Enalapril-hydrochlorothiazide and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antihypertensive effects are additive, which is usually desired but can cause excess hypotension or bradycardia. Beta-blockers may slightly raise potassium while thiazides lower it, and propranolol may mask hypoglycemia signs in patients on thiazide-impaired glucose control.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering via different mechanisms, with opposing minor effects on potassium.
What to do
Monitor blood pressure, heart rate and potassium when starting or adjusting doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Propranolol?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antihypertensive effects are additive, which is usually desired but can cause excess hypotension or bradycardia. Beta-blockers may slightly raise potassium while thiazides lower it, and propranolol may mask hypoglycemia signs in patients on thiazide-impaired glucose control.
How serious is the interaction between Enalapril-hydrochlorothiazide and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium when starting or adjusting doses.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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