Drug interactions
Enalapril-hydrochlorothiazide + Rifampin
Severity: Minor
Enalapril-hydrochlorothiazide and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent enzyme inducer and may modestly lower exposure to enalapril's active metabolite, enalaprilat. The effect on blood pressure control is probably small but could reduce antihypertensive effect.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Rifampin induction of hepatic and intestinal enzymes and transporters may increase enalapril clearance or reduce its conversion.
What to do
Monitor blood pressure after starting or stopping rifampin and adjust the antihypertensive dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Rifampin?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin is a potent enzyme inducer and may modestly lower exposure to enalapril's active metabolite, enalaprilat. The effect on blood pressure control is probably small but could reduce antihypertensive effect.
How serious is the interaction between Enalapril-hydrochlorothiazide and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping rifampin and adjust the antihypertensive dose if control changes.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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