Drug interactions
Enalapril-hydrochlorothiazide + Shark cartilage
Severity: Minor
Enalapril-hydrochlorothiazide and Shark cartilage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shark cartilage contains calcium and has been associated with hypercalcemia. Thiazides reduce urinary calcium excretion and could add to this effect. The risk is largely theoretical.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcium load from shark cartilage combined with reduced renal calcium excretion caused by hydrochlorothiazide.
What to do
Check serum calcium if shark cartilage is taken regularly with the thiazide. Stop the supplement if hypercalcemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Shark cartilage?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shark cartilage contains calcium and has been associated with hypercalcemia. Thiazides reduce urinary calcium excretion and could add to this effect. The risk is largely theoretical.
How serious is the interaction between Enalapril-hydrochlorothiazide and Shark cartilage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium if shark cartilage is taken regularly with the thiazide. Stop the supplement if hypercalcemia develops.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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