Drug interactions
Enalapril-hydrochlorothiazide + Sodium bicarbonate
Severity: Minor
Enalapril-hydrochlorothiazide and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium bicarbonate provides a sodium load that may reduce the antihypertensive effect of the combination and cause fluid retention. Its alkalinizing effect also alters the handling of some drugs. Clinically significant effects occur mainly with regular or high doses.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Sodium loading promotes volume expansion, opposing ACE inhibitor and diuretic effects.
What to do
Monitor blood pressure and fluid status if sodium bicarbonate is used regularly. Note that thiazides with bicarbonate can worsen metabolic alkalosis and hypokalemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Sodium bicarbonate?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium bicarbonate provides a sodium load that may reduce the antihypertensive effect of the combination and cause fluid retention. Its alkalinizing effect also alters the handling of some drugs. Clinically significant effects occur mainly with regular or high doses.
How serious is the interaction between Enalapril-hydrochlorothiazide and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and fluid status if sodium bicarbonate is used regularly. Note that thiazides with bicarbonate can worsen metabolic alkalosis and hypokalemia.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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