Drug interactions
Enalapril-hydrochlorothiazide + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Enalapril-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations cause fluid loss and electrolyte shifts. With an ACE inhibitor and a thiazide, this raises the risk of volume depletion, acute kidney injury and electrolyte-related arrhythmia or seizures.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep fluid and electrolyte losses add to diuretic effects and to ACE inhibitor-related reduction of renal perfusion.
What to do
Ensure good hydration and consider withholding the diuretic and ACE inhibitor on the day of bowel preparation. Check electrolytes and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations cause fluid loss and electrolyte shifts. With an ACE inhibitor and a thiazide, this raises the risk of volume depletion, acute kidney injury and electrolyte-related arrhythmia or seizures.
How serious is the interaction between Enalapril-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure good hydration and consider withholding the diuretic and ACE inhibitor on the day of bowel preparation. Check electrolytes and renal function in high-risk patients.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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