Drug interactions
Enalapril-hydrochlorothiazide + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Enalapril-hydrochlorothiazide and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations cause fluid and electrolyte disturbances. Combined with an ACE inhibitor and thiazide, the risks of dehydration, kidney injury and electrolyte-related arrhythmia or seizures increase.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Osmotic fluid loss and electrolyte shifts add to diuretic effects and reduced renal perfusion from ACE inhibition.
What to do
Encourage adequate fluid intake and consider holding the diuretic and ACE inhibitor around the preparation. Check electrolytes and renal function in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations cause fluid and electrolyte disturbances. Combined with an ACE inhibitor and thiazide, the risks of dehydration, kidney injury and electrolyte-related arrhythmia or seizures increase.
How serious is the interaction between Enalapril-hydrochlorothiazide and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Encourage adequate fluid intake and consider holding the diuretic and ACE inhibitor around the preparation. Check electrolytes and renal function in at-risk patients.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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