Drug interactions
Enalapril-hydrochlorothiazide + Synthetic human angiotensin ii
Severity: Moderate
Enalapril-hydrochlorothiazide and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase the pressor response to exogenous angiotensin II, so lower doses may be required. Angiotensin II is used for vasodilatory shock, where the response may be exaggerated.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Blockade of angiotensin II formation upregulates sensitivity to administered angiotensin II, and ACE inhibition may reduce its degradation.
What to do
Titrate angiotensin II carefully against blood pressure, starting at the low end of dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase the pressor response to exogenous angiotensin II, so lower doses may be required. Angiotensin II is used for vasodilatory shock, where the response may be exaggerated.
How serious is the interaction between Enalapril-hydrochlorothiazide and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II carefully against blood pressure, starting at the low end of dosing.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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