Drug interactions
Enalapril-hydrochlorothiazide + Ticarcillin
Severity: Minor
Enalapril-hydrochlorothiazide and Ticarcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may reduce tubular secretion of ticarcillin and raise its levels. Ticarcillin's sodium load and hypokalemic effect may also add to thiazide-induced hypokalemia.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion; additive potassium loss.
What to do
Monitor serum potassium during ticarcillin therapy. Adjust ticarcillin dose for renal function as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Ticarcillin?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may reduce tubular secretion of ticarcillin and raise its levels. Ticarcillin's sodium load and hypokalemic effect may also add to thiazide-induced hypokalemia.
How serious is the interaction between Enalapril-hydrochlorothiazide and Ticarcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during ticarcillin therapy. Adjust ticarcillin dose for renal function as usual.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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