Drug interactions
Enalapril-hydrochlorothiazide + Trilostane
Severity: Moderate
Enalapril-hydrochlorothiazide and Trilostane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilostane reduces adrenal steroid synthesis including aldosterone, which lessens potassium loss from thiazides. Combined with enalapril, which also lowers aldosterone, there is a risk of hyperkalemia and hypotension.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 3-beta-hydroxysteroid dehydrogenase lowers aldosterone, adding to ACE inhibitor potassium retention.
What to do
Monitor serum potassium, sodium and blood pressure when combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Trilostane?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilostane reduces adrenal steroid synthesis including aldosterone, which lessens potassium loss from thiazides. Combined with enalapril, which also lowers aldosterone, there is a risk of hyperkalemia and hypotension.
How serious is the interaction between Enalapril-hydrochlorothiazide and Trilostane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium and blood pressure when combined.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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