Drug interactions
Enalapril-hydrochlorothiazide + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Enalapril-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium and may cause ECG changes, and hydrochlorothiazide adds to this effect. The risk is higher with excessive beta-agonist doses.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 stimulated intracellular potassium shift and thiazide renal potassium loss; the ACE inhibitor partly offsets it.
What to do
Monitor serum potassium in patients at risk, such as those with cardiac disease or on high doses. Do not exceed the recommended inhaled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a beta-agonist, can lower serum potassium and may cause ECG changes, and hydrochlorothiazide adds to this effect. The risk is higher with excessive beta-agonist doses.
How serious is the interaction between Enalapril-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients at risk, such as those with cardiac disease or on high doses. Do not exceed the recommended inhaled dose.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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