Drug interactions
Enalapril-hydrochlorothiazide + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Enalapril-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol can lower serum potassium and may worsen ECG changes, and hydrochlorothiazide adds to the potassium loss. The effect is most relevant at high doses or in patients with cardiac disease.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 mediated cellular potassium uptake and thiazide-induced renal potassium wasting.
What to do
Monitor serum potassium in at-risk patients and keep the inhaled dose within the labeled range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol can lower serum potassium and may worsen ECG changes, and hydrochlorothiazide adds to the potassium loss. The effect is most relevant at high doses or in patients with cardiac disease.
How serious is the interaction between Enalapril-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in at-risk patients and keep the inhaled dose within the labeled range.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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