Drug interactions
Enalapril-hydrochlorothiazide + Willow bark
Severity: Minor
Enalapril-hydrochlorothiazide and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylates, and these may blunt the antihypertensive effect of ACE inhibitors and thiazides and affect renal function. The effect is likely smaller than with full-dose aspirin or NSAIDs.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylates inhibit prostaglandin synthesis, reducing renal vasodilation and sodium excretion.
What to do
Monitor blood pressure and renal function if willow bark is used regularly, particularly in dehydrated or older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Willow bark?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylates, and these may blunt the antihypertensive effect of ACE inhibitors and thiazides and affect renal function. The effect is likely smaller than with full-dose aspirin or NSAIDs.
How serious is the interaction between Enalapril-hydrochlorothiazide and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if willow bark is used regularly, particularly in dehydrated or older patients.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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