Drug interactions
Encainide + Sertraline
Severity: Moderate
Encainide and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encainide is a class IC antiarrhythmic activated and cleared by CYP2D6. Sertraline can weakly to moderately inhibit CYP2D6 at higher doses, which may alter parent drug and active metabolite levels. Proarrhythmic risk with encainide makes any change in exposure relevant.
What this interaction means in plain words
Encainide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6 by sertraline alters encainide metabolism.
What to do
Monitor the ECG (QRS and PR intervals) when starting or adjusting sertraline. Adjust the encainide dose according to response and tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Encainide with Sertraline?
MediHelp rates the interaction as moderate. Encainide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encainide is a class IC antiarrhythmic activated and cleared by CYP2D6. Sertraline can weakly to moderately inhibit CYP2D6 at higher doses, which may alter parent drug and active metabolite levels. Proarrhythmic risk with encainide makes any change in exposure relevant.
How serious is the interaction between Encainide and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG (QRS and PR intervals) when starting or adjusting sertraline. Adjust the encainide dose according to response and tolerance.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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