Drug interactions
Encorafenib + Felodipine
Severity: Moderate
Encorafenib and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so its effect on felodipine exposure is unpredictable. Felodipine levels may rise, causing hypotension and edema, or fall, causing loss of blood pressure control.
What this interaction means in plain words
Encorafenib and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Felodipine belongs to Cardiovascular.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib alters felodipine metabolism in an unpredictable direction.
What to do
Monitor blood pressure after starting or stopping encorafenib and titrate felodipine to response. Consider a non-CYP3A4-dependent antihypertensive if control is unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Encorafenib and Felodipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Felodipine?
MediHelp rates the interaction as moderate. Encorafenib and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so its effect on felodipine exposure is unpredictable. Felodipine levels may rise, causing hypotension and edema, or fall, causing loss of blood pressure control.
How serious is the interaction between Encorafenib and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping encorafenib and titrate felodipine to response. Consider a non-CYP3A4-dependent antihypertensive if control is unstable.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
