Drug interactions
Encorafenib + Fluoxetine
Severity: Major
Encorafenib and Fluoxetine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib prolongs the QT interval in a dose-dependent way, and fluoxetine can add to this effect. Combined use increases the risk of serious ventricular arrhythmia. Encorafenib may also induce CYP3A4 and slightly reduce fluoxetine levels.
What this interaction means in plain words
Encorafenib and Fluoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive prolongation of the QTc interval.
What to do
Avoid if possible. If necessary, monitor ECG and electrolytes and reduce or stop encorafenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Encorafenib and Fluoxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Fluoxetine?
MediHelp rates the interaction as major. Encorafenib and Fluoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib prolongs the QT interval in a dose-dependent way, and fluoxetine can add to this effect. Combined use increases the risk of serious ventricular arrhythmia. Encorafenib may also induce CYP3A4 and slightly reduce fluoxetine levels.
How serious is the interaction between Encorafenib and Fluoxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If necessary, monitor ECG and electrolytes and reduce or stop encorafenib if QTc becomes markedly prolonged.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
