Drug interactions
Encorafenib + Maprotiline
Severity: Major
Encorafenib and Maprotiline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use raises the risk of ventricular arrhythmias. Encorafenib's QT effect is dose-dependent.
What this interaction means in plain words
Encorafenib and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Maprotiline belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Avoid if an alternative antidepressant is feasible. If used, monitor ECG and electrolytes at baseline and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Maprotiline?
MediHelp rates the interaction as major. Encorafenib and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use raises the risk of ventricular arrhythmias. Encorafenib's QT effect is dose-dependent.
How serious is the interaction between Encorafenib and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antidepressant is feasible. If used, monitor ECG and electrolytes at baseline and during treatment.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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