Drug interactions
Encorafenib + Metaxalone
Severity: Moderate
Encorafenib and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed inhibitory and inducing effects on CYP3A4, so metaxalone exposure may rise or fall. Metaxalone is metabolized by several CYP enzymes including CYP3A4, so the clinical impact is probably modest but unpredictable.
What this interaction means in plain words
Encorafenib and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Metaxalone belongs to Musculoskeletal.
Why it happens
Encorafenib both inhibits and induces CYP3A4, altering metabolism of metaxalone, which is partly a CYP3A4 substrate.
What to do
Monitor for increased sedation or dizziness, or reduced muscle relaxant effect, and adjust the metaxalone dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Encorafenib and Metaxalone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metaxalone
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Metaxalone?
MediHelp rates the interaction as moderate. Encorafenib and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed inhibitory and inducing effects on CYP3A4, so metaxalone exposure may rise or fall. Metaxalone is metabolized by several CYP enzymes including CYP3A4, so the clinical impact is probably modest but unpredictable.
How serious is the interaction between Encorafenib and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or dizziness, or reduced muscle relaxant effect, and adjust the metaxalone dose according to response.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
