Drug interactions
Encorafenib + Mitoxantrone
Severity: Moderate
Encorafenib and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitoxantrone is a BCRP substrate and encorafenib may inhibit BCRP. Mitoxantrone exposure and toxicity, including myelosuppression and cardiotoxicity, may increase.
What this interaction means in plain words
Encorafenib and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Mitoxantrone belongs to Central Nervous System.
Why it happens
Inhibition of BCRP-mediated efflux of mitoxantrone by encorafenib.
What to do
Monitor blood counts and cardiac function, and consider mitoxantrone dose reduction if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Mitoxantrone?
MediHelp rates the interaction as moderate. Encorafenib and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitoxantrone is a BCRP substrate and encorafenib may inhibit BCRP. Mitoxantrone exposure and toxicity, including myelosuppression and cardiotoxicity, may increase.
How serious is the interaction between Encorafenib and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and consider mitoxantrone dose reduction if toxicity emerges.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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