Drug interactions
Encorafenib + Nicardipine
Severity: Moderate
Encorafenib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so nicardipine exposure may rise or fall unpredictably. This may cause either hypotension and edema or loss of blood pressure control.
What this interaction means in plain words
Encorafenib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Encorafenib has mixed CYP3A4 inhibitory and inductive effects on nicardipine metabolism.
What to do
Monitor blood pressure and heart rate closely after encorafenib is started or stopped, and adjust the nicardipine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Encorafenib and Nicardipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nicardipine
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Nicardipine?
MediHelp rates the interaction as moderate. Encorafenib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so nicardipine exposure may rise or fall unpredictably. This may cause either hypotension and edema or loss of blood pressure control.
How serious is the interaction between Encorafenib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely after encorafenib is started or stopped, and adjust the nicardipine dose accordingly.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
