Drug interactions
Encorafenib + Nimodipine
Severity: Moderate
Encorafenib and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so nimodipine exposure may rise or fall. This may cause either hypotension or reduced efficacy.
What this interaction means in plain words
Encorafenib and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Nimodipine belongs to Cardiovascular.
Why it happens
Mixed inhibition and induction of CYP3A4 by encorafenib alters nimodipine metabolism unpredictably.
What to do
Monitor blood pressure and clinical response and adjust the nimodipine dose accordingly. Consider an alternative if control is erratic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Nimodipine?
MediHelp rates the interaction as moderate. Encorafenib and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so nimodipine exposure may rise or fall. This may cause either hypotension or reduced efficacy.
How serious is the interaction between Encorafenib and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response and adjust the nimodipine dose accordingly. Consider an alternative if control is erratic.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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