Drug interactions
Encorafenib + Primaquine
Severity: Moderate
Encorafenib and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can prolong the QT interval, and primaquine may add to this effect. The combination may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Encorafenib and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Primaquine belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac repolarization.
What to do
Monitor ECG and electrolytes and correct abnormalities during combined use. Consider an alternative antimalarial if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Primaquine?
MediHelp rates the interaction as moderate. Encorafenib and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can prolong the QT interval, and primaquine may add to this effect. The combination may increase the risk of ventricular arrhythmia.
How serious is the interaction between Encorafenib and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and correct abnormalities during combined use. Consider an alternative antimalarial if QTc rises significantly.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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