Drug interactions
Encorafenib + Regorafenib
Severity: Moderate
Encorafenib and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed inhibitory and inducing effects on CYP3A4, so regorafenib exposure may either rise or fall unpredictably. This could lead to increased toxicity or reduced antitumor efficacy of regorafenib.
What this interaction means in plain words
Encorafenib and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Regorafenib belongs to Oncology.
Why it happens
Encorafenib both inhibits and induces CYP3A4, altering regorafenib metabolism.
What to do
Monitor for regorafenib toxicity (liver tests, blood pressure, skin) and for loss of efficacy. Adjust regorafenib dosing according to tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Regorafenib?
MediHelp rates the interaction as moderate. Encorafenib and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed inhibitory and inducing effects on CYP3A4, so regorafenib exposure may either rise or fall unpredictably. This could lead to increased toxicity or reduced antitumor efficacy of regorafenib.
How serious is the interaction between Encorafenib and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for regorafenib toxicity (liver tests, blood pressure, skin) and for loss of efficacy. Adjust regorafenib dosing according to tolerability.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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