Drug interactions
Encorafenib + Ritonavir
Severity: Major
Encorafenib and Ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir raises encorafenib concentrations by inhibiting CYP3A4. This can increase adverse effects including QT prolongation and dermatologic or ocular toxicity.
What this interaction means in plain words
Encorafenib and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Ritonavir belongs to Anti Virals.
Why it happens
Strong CYP3A4 inhibition by ritonavir reduces encorafenib clearance.
What to do
Avoid concomitant use. If unavoidable, reduce the encorafenib dose per labeling and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Ritonavir?
MediHelp rates the interaction as major. Encorafenib and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir raises encorafenib concentrations by inhibiting CYP3A4. This can increase adverse effects including QT prolongation and dermatologic or ocular toxicity.
How serious is the interaction between Encorafenib and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use. If unavoidable, reduce the encorafenib dose per labeling and monitor ECG and electrolytes.
What other medicines interact with Ritonavir?
MediHelp also lists interactions of Ritonavir with, for example, Alfuzosin, Amiodarone, Avanafil. The full list is on the Ritonavir page.
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