Drug interactions
Encorafenib + Roflumilast
Severity: Moderate
Encorafenib and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed CYP3A4 inhibiting and inducing effects, so roflumilast exposure could either rise or fall unpredictably. This may lead to increased adverse effects or reduced efficacy.
What this interaction means in plain words
Encorafenib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Roflumilast belongs to Respiratory.
Why it happens
Encorafenib both inhibits and induces CYP3A4, altering roflumilast metabolism in an unpredictable direction.
What to do
Monitor COPD control and roflumilast adverse effects such as diarrhea, weight loss and mood changes, and adjust therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Roflumilast?
MediHelp rates the interaction as moderate. Encorafenib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed CYP3A4 inhibiting and inducing effects, so roflumilast exposure could either rise or fall unpredictably. This may lead to increased adverse effects or reduced efficacy.
How serious is the interaction between Encorafenib and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor COPD control and roflumilast adverse effects such as diarrhea, weight loss and mood changes, and adjust therapy as needed.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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