Drug interactions
Encorafenib + Simvastatin
Severity: Moderate
Encorafenib and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can both inhibit and induce CYP3A4 and also inhibits hepatic uptake and efflux transporters such as OATP1B1, OATP1B3 and BCRP. Simvastatin exposure may therefore rise, increasing the risk of myopathy, or fall, reducing lipid-lowering effect, depending on which effect predominates.
What this interaction means in plain words
Encorafenib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Simvastatin belongs to Cardiovascular.
Why it happens
Mixed CYP3A4 inhibition and induction plus inhibition of OATP1B1/1B3 and BCRP transporters by encorafenib alters simvastatin disposition.
What to do
Monitor for muscle pain, weakness and CK elevation, and consider using the lowest effective simvastatin dose or switching to a statin less dependent on CYP3A4. Check lipid response during prolonged co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Simvastatin?
MediHelp rates the interaction as moderate. Encorafenib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can both inhibit and induce CYP3A4 and also inhibits hepatic uptake and efflux transporters such as OATP1B1, OATP1B3 and BCRP. Simvastatin exposure may therefore rise, increasing the risk of myopathy, or fall, reducing lipid-lowering effect, depending on which effect predominates.
How serious is the interaction between Encorafenib and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation, and consider using the lowest effective simvastatin dose or switching to a statin less dependent on CYP3A4. Check lipid response during prolonged co-therapy.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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