Drug interactions
Encorafenib + Sulphasalazine
Severity: Minor
Encorafenib and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is a substrate of the efflux transporter BCRP, which limits its intestinal absorption. Encorafenib may inhibit BCRP and raise systemic sulfasalazine exposure, potentially increasing dose-related adverse effects such as gastrointestinal upset, headache and blood disorders.
What this interaction means in plain words
Encorafenib and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of intestinal BCRP efflux by encorafenib increases sulfasalazine absorption and systemic exposure.
What to do
Monitor for sulfasalazine adverse effects such as nausea, rash and cytopenias when starting encorafenib. Consider reducing the sulfasalazine dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Sulphasalazine?
MediHelp rates the interaction as minor. Encorafenib and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is a substrate of the efflux transporter BCRP, which limits its intestinal absorption. Encorafenib may inhibit BCRP and raise systemic sulfasalazine exposure, potentially increasing dose-related adverse effects such as gastrointestinal upset, headache and blood disorders.
How serious is the interaction between Encorafenib and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine adverse effects such as nausea, rash and cytopenias when starting encorafenib. Consider reducing the sulfasalazine dose if toxicity appears.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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