Drug interactions
Encorafenib + Tamsulosin
Severity: Moderate
Encorafenib and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so tamsulosin exposure may rise or fall unpredictably. This may cause hypotension or reduced urinary symptom control.
What this interaction means in plain words
Encorafenib and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Tamsulosin belongs to Genitourinary.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib alters tamsulosin metabolism.
What to do
Monitor blood pressure and symptom response when starting or stopping encorafenib. Adjust tamsulosin or switch agents based on effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Tamsulosin?
MediHelp rates the interaction as moderate. Encorafenib and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so tamsulosin exposure may rise or fall unpredictably. This may cause hypotension or reduced urinary symptom control.
How serious is the interaction between Encorafenib and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptom response when starting or stopping encorafenib. Adjust tamsulosin or switch agents based on effect.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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