Drug interactions
Encorafenib + Vardenafil
Severity: Moderate
Encorafenib and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can prolong the QT interval, and vardenafil may add a small further effect. The combination can raise the risk of serious ventricular arrhythmia, especially with other risk factors.
What this interaction means in plain words
Encorafenib and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Vardenafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG and electrolytes before and during combined use. Consider an alternative to vardenafil if the QTc increases significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Vardenafil?
MediHelp rates the interaction as moderate. Encorafenib and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can prolong the QT interval, and vardenafil may add a small further effect. The combination can raise the risk of serious ventricular arrhythmia, especially with other risk factors.
How serious is the interaction between Encorafenib and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before and during combined use. Consider an alternative to vardenafil if the QTc increases significantly.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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