Drug interactions
Encorafenib + Verapamil
Severity: Major
Encorafenib and Verapamil: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and can raise encorafenib exposure. Higher encorafenib levels may increase adverse effects such as QT prolongation and dermatologic or other toxicities.
What this interaction means in plain words
Encorafenib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4-mediated metabolism of encorafenib, a CYP3A4 substrate.
What to do
Prefer an alternative to verapamil. If unavoidable, reduce the encorafenib dose to about half, monitor QTc and toxicity, and restore the usual dose 3-5 half-lives after stopping verapamil.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Verapamil?
MediHelp rates the interaction as major. Encorafenib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Verapamil is a moderate CYP3A4 inhibitor and can raise encorafenib exposure. Higher encorafenib levels may increase adverse effects such as QT prolongation and dermatologic or other toxicities.
How serious is the interaction between Encorafenib and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to verapamil. If unavoidable, reduce the encorafenib dose to about half, monitor QTc and toxicity, and restore the usual dose 3-5 half-lives after stopping verapamil.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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