Drug interactions
Encorafenib + Vinblastine
Severity: Moderate
Encorafenib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so vinblastine exposure may rise or fall unpredictably. This could cause increased toxicity or reduced antitumor efficacy.
What this interaction means in plain words
Encorafenib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Encorafenib has mixed CYP3A4 inhibitory and inductive effects on vinblastine metabolism.
What to do
Monitor for vinblastine toxicity and therapeutic response, and adjust the vinblastine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Vinblastine?
MediHelp rates the interaction as moderate. Encorafenib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so vinblastine exposure may rise or fall unpredictably. This could cause increased toxicity or reduced antitumor efficacy.
How serious is the interaction between Encorafenib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vinblastine toxicity and therapeutic response, and adjust the vinblastine dose accordingly.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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