Drug interactions
Enoxaparin + Epoprostenol
Severity: Moderate
Enoxaparin and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent inhibitor of platelet aggregation and a vasodilator. Together with enoxaparin it can increase the risk of bleeding.
What this interaction means in plain words
Enoxaparin and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive effect: prostacyclin-mediated platelet inhibition plus enoxaparin anticoagulation.
What to do
Monitor for bleeding signs and hemoglobin and platelet counts during co-therapy. Review the need for both drugs, especially around invasive procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Enoxaparin with Epoprostenol?
MediHelp rates the interaction as moderate. Enoxaparin and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent inhibitor of platelet aggregation and a vasodilator. Together with enoxaparin it can increase the risk of bleeding.
How serious is the interaction between Enoxaparin and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and hemoglobin and platelet counts during co-therapy. Review the need for both drugs, especially around invasive procedures.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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