Drug interactions
Enoxaparin + Eprosartan
Severity: Moderate
Enoxaparin and Eprosartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin can suppress aldosterone secretion, and eprosartan blocks angiotensin II effects on aldosterone. Combined use may cause hyperkalemia, particularly in renal impairment, diabetes or prolonged therapy.
What this interaction means in plain words
Enoxaparin and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Eprosartan belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone synthesis adds to angiotensin receptor blockade, reducing renal potassium excretion.
What to do
Monitor serum potassium at baseline and periodically during prolonged therapy. Take extra care in patients with renal impairment or other hyperkalemia risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Eprosartan?
MediHelp rates the interaction as moderate. Enoxaparin and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enoxaparin can suppress aldosterone secretion, and eprosartan blocks angiotensin II effects on aldosterone. Combined use may cause hyperkalemia, particularly in renal impairment, diabetes or prolonged therapy.
How serious is the interaction between Enoxaparin and Eprosartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium at baseline and periodically during prolonged therapy. Take extra care in patients with renal impairment or other hyperkalemia risk factors.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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