Drug interactions
Enoxaparin + Levonorgestrel
Severity: Minor
Enoxaparin and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levonorgestrel, mainly in estrogen-containing products, can contribute to thrombotic risk, but progestin-only use, including emergency contraception, has little effect on thrombosis. It does not meaningfully impair enoxaparin's anticoagulant effect.
What this interaction means in plain words
Enoxaparin and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enoxaparin belongs to Cardiovascular; Levonorgestrel belongs to Endocrine.
Why it happens
Theoretical pharmacodynamic opposition via hormonal effects on coagulation; not an established direct interaction.
What to do
No dose change needed; in patients with active thromboembolism prefer non-estrogen or non-hormonal contraception.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Enoxaparin with Levonorgestrel?
MediHelp rates the interaction as minor. Enoxaparin and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levonorgestrel, mainly in estrogen-containing products, can contribute to thrombotic risk, but progestin-only use, including emergency contraception, has little effect on thrombosis. It does not meaningfully impair enoxaparin's anticoagulant effect.
How serious is the interaction between Enoxaparin and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; in patients with active thromboembolism prefer non-estrogen or non-hormonal contraception.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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